In order for the embryo to be implanted into uterus lining, it has to divide and form an embryo that is multi-cell with blastocyst. The blastocyst will be coated with a material similar to a gel, called ZonaPellucida or just Zona. For the blastocyst to be fully implanted inside a uterus, it needs to have cells breaking through the Zona. Such a process is known by the name hatching.
It is possible that the blastocyst’s ability to hatch will be impaired. That is exactly when assisted hatching becomes a viable option that is considered in the CRGH IVF process. The laboratory procedure is when early embryo Zona will be mechanically or chemically weakened in order to help the embryo to easily hatch, thus allowing uterus lining implantation. The technique was initially developed in 1990, then adopted by different IVF clinics and improved. Nowadays, it is accepted as a highly effective fertility treatment because of the really high success rates.
When To Consider Assisted Hatching
There are various cases when you should consider assisted hatching, including:
- When the female partner is older than the age of 37.
- Embryo quality factor – when the embryo has a poor quality and cell division rates are low or there is excessive fragmentation present.
- Egg quality and quantity – usually when day 3 FSH level is too elevated or when there is a low AMH level.
- Zona factor – when the embryo has a thicker outer shell or there is a ZonaPellucida that is too thick.
- Previous IVF failures – when women went through at least one IVF cycle in the past and failed.
IVF Assisted Hatching
It is highly frustrating to deal with IVF failure from a psychological point of view. Couples often find themselves faced with fertility problems and assisted hatching is quite commonly recommended, especially when the couple is running out of fertility time. It was noticed that the embryos that have thin ZP have higher implantation rates. That is why embryo hatching chances are increased when ZPs have minor defects that are created by the doctor. It is difficult to have the procedure done so only true professionals have to be considered.
Assisted Hatching Types:
- Partial Zona Dissection – normally referred to as Mechanical Assisted Hatching
- Acid Tyrode Assisted Hatching
- Laser Hatching
- ZonaPellucidaPronase Thinning Assisted Hatching
The reason why we always recommend that only a trained embryologist performs assisted hatching is that this will drastically increase the possibility of success. Live birth rates following any assisted hatching procedure type will vary from one clinic to the next. Female fertility will diminish as time passes so if you are younger, you have a much higher possibility of success.
On the whole, it is basically important that you deal only with the professionals that have the high experience that is necessary to perform the procedure properly. This is not at all easy to do. You need to always find the option that is the best for you. Have patience and you will always find the best possible clinic to consider.